"Touch Me I'm Sick" is a song by the American alternative rock band Mudhoney. It was recorded in April 1988 at Seattle's Reciprocal Recording studio with producer Jack Endino. "Touch Me I'm Sick" was released as Mudhoney's debut single by independent record label Sub Pop on August 1, 1988. The song's lyrics, which feature dark humor, are a sarcastic take on issues such as disease and violent sex.
When it was first released, "Touch Me I'm Sick" was a hit on college radio. Its heavily distorted and fuzzy guitars, snarling vocals, blunt bass line and energetic drumming contributed to a dirty sound that influenced many local musicians, and helped develop the nascent Seattle grunge scene. According to AllMusic, "the song's raw, primal energy made it an instant anthem which still stands as one of [grunge's] all-time classics". A staple of Mudhoney's live shows, it remains the band's most recognizable song.